FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury.

Lee B, Oh Y, Cho E, DiAntonio A, Cavalli V, Shin JE, Choi HW, Cho Y. J Biol Chem. 2022 Jan 28


The human cognition-enhancing CORD7 mutation increases active zone number and synaptic release.

Paul MM, Dannhäuser S, Morris L, Mrestani A, Hübsch M, Gehring J, Hatzopoulos GN, Pauli M, Auger GM, Bornschein G, Scholz N, Ljaschenko D, Müller M, Sauer M, Schmidt H, Kittel RJ, DiAntonio A, Vakonakis I, Heckmann M, Langenhan T. Brain. 2022 Jan 12


Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients.

Bloom AJ, Mao X, Strickland A, Sasaki Y, Milbrandt J, DiAntonio A. Mol Neurodegener. 2022 Jan 6


SARM1 is a metabolic sensor activated by an increased NMN/NAD+ ratio to trigger axon degeneration.

Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, Manik MK, Bosanac T, Landsberg MJ, Kerry PS, Mobli M, Hughes RO, Milbrandt J, Kobe B, DiAntonio A, Ve T. Neuron. 2021 Apr 7


Bidirectional regulation of glial potassium buffering – glioprotection versus neuroprotection.

Li H, Lones L, DiAntonio A. Elife. 2021 Mar 1


SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration.

Chen YH, Sasaki Y, DiAntonio A, Milbrandt J. Exp Neurol. 2021 May


Multiple domain interfaces mediate SARM1 autoinhibition.

Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J.Proc Natl Acad Sci U S A. 2021 Jan 26


Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.

Hughes RO, Bosanac T, Mao X, Engber TM, DiAntonio A, Milbrandt J, Devraj R, Krauss R. Cell Rep. 2021 Jan 5


SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration.

Sasaki Y, Kakita H, Kubota S, Sene A, Lee TJ, Ban N, Dong Z, Lin JB, Boye SL, DiAntonio A, Boye SE, Apte RS, Milbrandt J. Elife. 2020 Oct 27


Rapid and extraction-free detection of SARS-CoV-2 from saliva by colorimetric reverse-transcription loop-mediated isothermal amplification.

Lalli MA, Langmade SJ, Chen X, Fronick CC, Sawyer CS, Burcea LC, Wilkinson MN, Fulton RS, Heinz M, Buchser WJ, Head RD, Mitra RD, Milbrandt J. Clin Chem. 2020 Oct 24


High-throughput single-cell functional elucidation of neurodevelopmental disease-associated genes reveals convergent mechanisms altering neuronal differentiation.

Lalli MA, Avey D, Dougherty JD, Milbrandt J, Mitra RD. Genome Res. 2020 Sep 30


SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration.

Ko KW, Milbrandt J, DiAntonio A. J Cell Biol. 2020 Aug 3


cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons.

Sasaki Y, Engber TM, Hughes RO, Figley MD, Wu T, Bosanac T, Devraj R, Milbrandt J, Krauss R, DiAntonio A. Exp Neurol. 2020 July


Peripheral nerve resident macrophages share tissue-specific programming and features of activated microglia.

Wang PL, Yim AKY, Kim KW, Avey D, Czepielewski RS, Colonna M, Milbrandt J, Randolph GJ. Nat Commun. 2020 May 21


Rapid and extraction-free detection of SARS-CoV-2 from saliva with colorimetric LAMP.

Lalli MA, Chen X, Langmade SJ, Fronick CC, Sawyer CS, Burcea LC, Fulton RS, Heinz M, Buchser WJ, Head RD, Mitra RD, Milbrandt J. medRxiv. 2020 May 11


Disrupting insulin signaling in Schwann cells impairs myelination and induces a sensory neuropathy.

Hackett AR, Strickland A, Milbrandt J. Glia. 2020 May


Models of Axon Degeneration in Drosophila Larvae.

Brace EJ, DiAntonio A. Methods Mol Biol. 2020


Cell-autonomous expression of the acid hydrolase galactocerebrosidase.

Mikulka CR, Dearborn JT, Benitez BA, Strickland A, Liu L, Milbrandt J, Sands MS. Proc Natl Acad Sci U S A. 2020 Apr 21


The SARM1 axon degeneration pathway: control of the NAD+ metabolome regulates axon survival in health and disease.

Figley MD, DiAntonio A. Curr Opin Neurobiol. 2020 Apr 17


SIK3 suppresses neuronal hyperexcitability by regulating the glial capacity to buffer K+ and water.

Li H, Russo A, DiAntonio A. J Cell Biol. 2019 Dec 2.


Molecular Tuning of the Axonal Mitochondrial Ca2+ Uniporter Ensures Metabolic Flexibility of Neurotransmission.

Ashrafi G, de Juan-Sanz J, Farrell RJ, Ryan TA. Neuron. 2020 Feb 19


DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration.

Summers DW, Frey E, Walker LJ, Milbrandt J, DiAntonio A. Mol Neurobiol. 2019 Nov 7.


Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program.

Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A. JCI Insight. 2019 Sept 5.


Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome.

Russo A, DiAntonio A. Cell Rep. 2019 Sept 3.


TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death.

Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT. Science. 2019 Aug 23.


DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury.

Shin JE, Ha H, Kim YK, Cho Y, DiAntonio A. Neurobiol Dis. 2019 July.


Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy.

DiAntonio A. Pain. 2019 May.


The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat.

Russo A, Goel P, Brace EJ, Buser C, Dickman D, DiAntonio A. EMBO Rep. 2019 March.


Gene therapy targeting SARM1 blocks pathological axon degeneration in mice.

Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, MilbrandtJ. J Exp Med. 2019 Feb 4.


HSP90 is a chaperone for DLK and is required for axon injury signaling.

Karney-Grobe S, Russo A, Frey E, Milbrandt J, DiAntonio A. Proc Natl Acad Sci U S A. 2018 Oct 16.


Palmitoylation enables MAPK-dependent proteostasis of axon survival factors.

Summers DW, Milbrandt J, DiAntonio A. Proc Natl Acad Sci U S A. 2018 Sep 11.


TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling.

Frey E, Karney-Grobe S, Krolak T, Milbrandt J, DiAntonio A. eNeuro. 2018 May 30.


TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes.

Essuman K, Summers DW, Sasaki Y, Mao X, Yim AKY, DiAntonio A, Milbrandt J. Curr Biol. 2018 Feb 5.